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This World Health Organization guideline brings together recommendations on care for women with sickle-cell disease during pregnancy, childbirth, and the period between pregnancies. It is written for health professionals and programme teams, with attention to the clinical circumstances that make pregnancy particularly complex for women living with this inherited condition.
The document explains how evidence was identified, assessed, and used to formulate recommendations. Supporting material addresses implementation, organization of care, monitoring, and research priorities, while annexes record contributors, decision-making outcomes, and declared interests. This complete 2025 publication includes its references and links to supplementary evidence-to-decision material.
WHO recommendations on the management of sickle-cell disease during pregnancy, childbirth and the interpregnancy period. Geneva: World Health Organization; 2025. Licence: CC BY-NC-SA 3.0 IGO. Original English edition unchanged.